Assay Detail
Functional
CHEMBL998728
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Antiviral activity against HIV1 3B in MT4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 8.28 | 9.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL204656 | ELVITEGRAVIR | 4.0 | 1 | 9.43 |
| CHEMBL379664 | — | — | 1 | 7.12 |
| CHEMBL498504 | — | — | 1 | - |
| CHEMBL497661 | — | — | 1 | - |
| CHEMBL497490 | — | — | 1 | - |
| CHEMBL497489 | — | — | 1 | - |
| CHEMBL526269 | — | — | 1 | - |
| CHEMBL444410 | — | — | 1 | - |
| CHEMBL498491 | — | — | 1 | - |
| CHEMBL498490 | — | — | 1 | - |
| CHEMBL498321 | — | — | 1 | - |
| CHEMBL497476 | — | — | 1 | - |
| CHEMBL497475 | — | — | 1 | - |
| CHEMBL496491 | — | — | 1 | - |
| CHEMBL496476 | — | — | 1 | - |
| CHEMBL497506 | — | — | 1 | - |
| CHEMBL526642 | — | — | 1 | - |
| CHEMBL497505 | — | — | 1 | - |
| CHEMBL522229 | — | — | 1 | - |
| CHEMBL458280 | — | — | 1 | - |
| CHEMBL458279 | — | — | 1 | - |
| CHEMBL458483 | — | — | 1 | - |
| CHEMBL511508 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL204656 | ELVITEGRAVIR | EC50 | = | 0.37 | nM | 9.43 |
| CHEMBL379664 | — | EC50 | = | 76.3 | nM | 7.12 |
| CHEMBL498504 | — | EC50 | > | 42800.0 | nM | - |
| CHEMBL497661 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL497490 | — | EC50 | > | 2200.0 | nM | - |
| CHEMBL497489 | — | EC50 | > | 2400.0 | nM | - |
| CHEMBL526269 | — | EC50 | > | 138100.0 | nM | - |
| CHEMBL444410 | — | EC50 | > | 44900.0 | nM | - |
| CHEMBL498491 | — | EC50 | > | 9800.0 | nM | - |
| CHEMBL498490 | — | EC50 | > | 27400.0 | nM | - |
| CHEMBL498321 | — | EC50 | > | 220500.0 | nM | - |
| CHEMBL497476 | — | EC50 | > | 224000.0 | nM | - |
| CHEMBL497475 | — | EC50 | > | 22600.0 | nM | - |
| CHEMBL496491 | — | EC50 | > | 17000.0 | nM | - |
| CHEMBL496476 | — | EC50 | > | 17500.0 | nM | - |
| CHEMBL497506 | — | EC50 | > | 21100.0 | nM | - |
| CHEMBL526642 | — | EC50 | > | 4200.0 | nM | - |
| CHEMBL497505 | — | EC50 | > | 5200.0 | nM | - |
| CHEMBL522229 | — | EC50 | > | 4200.0 | nM | - |
| CHEMBL458280 | — | EC50 | > | 3600.0 | nM | - |
| CHEMBL458279 | — | EC50 | > | 5300.0 | nM | - |
| CHEMBL458483 | — | EC50 | > | 9900.0 | nM | - |
| CHEMBL511508 | — | EC50 | > | 22700.0 | nM | - |