Assay Detail

CHEMBL998731

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Functional

Antiviral activity against HIV1

ChEMBL ↗

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Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

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Primary target Human immunodeficiency virus 1

CHEMBL378

Anchored from Assay target.

Protein identity Human immunodeficiency virus 1

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Human immunodeficiency virus 1
Confidence	1 — Organism
Curated By	Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

Type	ORGANISM
Organism	Human immunodeficiency virus 1

Publication

Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors.

Pasquini S, Mugnaini C, Tintori C, Botta M, Trejos A, Arvela RK, Larhed M, Witvrouw M, Michiels M, Christ F, Debyser Z, Corelli F.
J Med Chem (2008) 51 : 5125 -5129
PubMed 18665580 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	9.05	9.05

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL204656	ELVITEGRAVIR	4.0	1	9.05

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL204656	ELVITEGRAVIR	EC50	=	0.9	nM	9.05