Assay Detail
Functional
CHEMBL998752
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at CRF1 receptor expressed in mouse AtT20 cells assessed as inhibition of sauvagine-stimulated cAMP accumulation
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | AtT20 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Corticotropin-releasing factor receptor 1 (CHEMBL1800) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
2-Arylpyrimidines: novel CRF-1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.20 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL525716 | — | — | 1 | 9.00 |
| CHEMBL497653 | — | — | 1 | 8.15 |
| CHEMBL438888 | — | — | 1 | 7.92 |
| CHEMBL497652 | — | — | 1 | 7.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL525716 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL497653 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL438888 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL497652 | — | IC50 | = | 19.0 | nM | 7.72 |