Assay Detail
Binding
CHEMBL998766
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Inhibition of CDC7-DBF4
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cell division cycle 7-related protein kinase (CHEMBL5443) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
4-(1H-indazol-5-yl)-6-phenylpyrimidin-2(1H)-one analogs as potent CDC7 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.26 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL501724 | — | — | 1 | 8.52 |
| CHEMBL508883 | — | — | 1 | 8.30 |
| CHEMBL500662 | — | — | 1 | 8.22 |
| CHEMBL502268 | — | — | 1 | 8.00 |
| CHEMBL526133 | — | — | 1 | 8.00 |
| CHEMBL450151 | — | — | 1 | 7.52 |
| CHEMBL501732 | — | — | 1 | 7.40 |
| CHEMBL501731 | — | — | 1 | 7.00 |
| CHEMBL502538 | — | — | 1 | 6.96 |
| CHEMBL502269 | — | — | 1 | 6.82 |
| CHEMBL501462 | — | — | 1 | 6.46 |
| CHEMBL524866 | — | — | 1 | 6.00 |
| CHEMBL501723 | — | — | 1 | 5.14 |
| CHEMBL524899 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL501724 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL508883 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL500662 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL502268 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL526133 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL450151 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL501732 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL501731 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL502538 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL502269 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL501462 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL524866 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL501723 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL524899 | — | IC50 | > | 13000.0 | nM | - |