Assay Detail
Functional
CHEMBL998988
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Vasodilatory activity in Wistar rat endothelium-denuded cross tolerant thoracic aortic ring assessed as inhibition of phenylephrine-induced contraction preincubated with 0.55 mM GTN for 1 hr followed by washing
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of some novel organic nitrates and comparative in vitro study of their vasodilator profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 5.81 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494017 | — | — | 1 | 6.66 |
| CHEMBL466213 | — | — | 1 | 6.32 |
| CHEMBL494177 | — | — | 1 | 6.31 |
| CHEMBL467454 | — | — | 1 | 6.21 |
| CHEMBL467456 | — | — | 1 | 6.19 |
| CHEMBL465935 | — | — | 1 | 6.17 |
| CHEMBL466616 | — | — | 1 | 6.11 |
| CHEMBL512439 | — | — | 1 | 6.00 |
| CHEMBL453170 | — | — | 1 | 5.80 |
| CHEMBL502853 | — | — | 1 | 5.62 |
| CHEMBL730 | NITROGLYCERIN | 4.0 | 1 | 5.36 |
| CHEMBL494178 | — | — | 1 | 5.35 |
| CHEMBL495366 | — | — | 1 | 5.21 |
| CHEMBL455789 | — | — | 1 | 5.19 |
| CHEMBL501932 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494017 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL466213 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL494177 | — | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL467454 | — | EC50 | = | 610.0 | nM | 6.21 |
| CHEMBL467456 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL465935 | — | EC50 | = | 680.0 | nM | 6.17 |
| CHEMBL466616 | — | EC50 | = | 780.0 | nM | 6.11 |
| CHEMBL512439 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL453170 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL502853 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL730 | NITROGLYCERIN | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL494178 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL495366 | — | EC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL455789 | — | EC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL501932 | — | EC50 | = | 20000.0 | nM | 4.70 |