Assay Detail
Functional
CHEMBL998990
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Vasodilatory activity in Wistar rat endothelium-denuded thoracic aortic ring assessed as inhibition of phenylephrine-induced contraction drug treated 30 mins after ALDH2 inhibitor benomyl treatment
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of some novel organic nitrates and comparative in vitro study of their vasodilator profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 6.48 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL453170 | — | — | 1 | 6.92 |
| CHEMBL494017 | — | — | 1 | 6.85 |
| CHEMBL502853 | — | — | 1 | 6.80 |
| CHEMBL466213 | — | — | 1 | 6.64 |
| CHEMBL494177 | — | — | 1 | 6.64 |
| CHEMBL467454 | — | — | 1 | 6.50 |
| CHEMBL512439 | — | — | 1 | 6.50 |
| CHEMBL465935 | — | — | 1 | 6.48 |
| CHEMBL467456 | — | — | 1 | 6.46 |
| CHEMBL466616 | — | — | 1 | 6.44 |
| CHEMBL730 | NITROGLYCERIN | 4.0 | 1 | 6.38 |
| CHEMBL494178 | — | — | 1 | 6.29 |
| CHEMBL495366 | — | — | 1 | 6.22 |
| CHEMBL455789 | — | — | 1 | 6.20 |
| CHEMBL501932 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL453170 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL494017 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL502853 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL466213 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL494177 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL467454 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL512439 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL465935 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL467456 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL466616 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL730 | NITROGLYCERIN | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL494178 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL495366 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL455789 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL501932 | — | EC50 | = | 1500.0 | nM | 5.82 |