Assay Detail
Functional
CHEMBL998992
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Vasodilatory activity in Wistar rat endothelium-denuded thoracic aortic ring assessed as inhibition of phenylephrine-induced contraction drug treated 30 mins after 1 uM soluble guanylate cyclase heme site inhibitor ODQ treatment
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of some novel organic nitrates and comparative in vitro study of their vasodilator profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 4.65 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494017 | — | — | 1 | 5.00 |
| CHEMBL494177 | — | — | 1 | 4.92 |
| CHEMBL467454 | — | — | 1 | 4.75 |
| CHEMBL465935 | — | — | 1 | 4.75 |
| CHEMBL466616 | — | — | 1 | 4.68 |
| CHEMBL466213 | — | — | 1 | 4.68 |
| CHEMBL467456 | — | — | 1 | 4.66 |
| CHEMBL453170 | — | — | 1 | 4.54 |
| CHEMBL512439 | — | — | 1 | 4.52 |
| CHEMBL502853 | — | — | 1 | 4.52 |
| CHEMBL494178 | — | — | 1 | 4.18 |
| CHEMBL495366 | — | — | 1 | - |
| CHEMBL455789 | — | — | 1 | - |
| CHEMBL501932 | — | — | 1 | - |
| CHEMBL730 | NITROGLYCERIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494017 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL494177 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL467454 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL465935 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL466616 | — | EC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL466213 | — | EC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL467456 | — | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL453170 | — | EC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL512439 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL502853 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL494178 | — | EC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL495366 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL455789 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL501932 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL730 | NITROGLYCERIN | EC50 | > | 100000.0 | nM | - |