Assay Detail
Binding
CHEMBL999087
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Binding affinity to human AChE
2
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 1 | 4.89 | 4.89 |
| Ki | 1 | 9.17 | 9.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL208599 | HUPRINE X | — | 1 | 9.17 |
| CHEMBL1025 | ISOFLUROPHATE | 4.0 | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL208599 | HUPRINE X | Ki | = | 0.67 | nM | 9.17 |
| CHEMBL1025 | ISOFLUROPHATE | Kd | = | 13000.0 | nM | 4.89 |