Assay Detail
Binding
CHEMBL999364
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Mycobacterium tuberculosis MbtA expressed in Escherichia coli assessed as ATP-[32P]Ppi exchange
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Salicyl-AMP ligase / salicyl-S-ArCP synthetase (CHEMBL5662) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Inhibition of siderophore biosynthesis by 2-triazole substituted analogues of 5'-O-[N-(salicyl)sulfamoyl]adenosine: antibacterial nucleosides effective against Mycobacterium tuberculosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 32 | 8.95 | 9.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL611772 | — | — | 1 | 9.54 |
| CHEMBL611766 | — | — | 1 | 9.49 |
| CHEMBL612049 | — | — | 1 | 9.39 |
| CHEMBL612048 | — | — | 1 | 9.34 |
| CHEMBL611785 | — | — | 1 | 9.32 |
| CHEMBL609105 | — | — | 1 | 9.27 |
| CHEMBL612052 | — | — | 1 | 9.24 |
| CHEMBL608839 | — | — | 1 | 9.23 |
| CHEMBL611784 | — | — | 1 | 9.21 |
| CHEMBL611782 | — | — | 1 | 9.21 |
| CHEMBL611775 | — | — | 1 | 9.20 |
| CHEMBL609101 | — | — | 1 | 9.11 |
| CHEMBL611780 | — | — | 1 | 9.07 |
| CHEMBL612041 | — | — | 1 | 9.06 |
| CHEMBL611774 | — | — | 1 | 9.05 |
| CHEMBL608842 | — | — | 1 | 9.02 |
| CHEMBL611767 | — | — | 1 | 9.02 |
| CHEMBL611783 | — | — | 1 | 9.02 |
| CHEMBL612040 | — | — | 1 | 8.95 |
| CHEMBL612037 | — | — | 1 | 8.89 |
| CHEMBL608843 | — | — | 1 | 8.85 |
| CHEMBL609100 | — | — | 1 | 8.83 |
| CHEMBL612057 | — | — | 1 | 8.82 |
| CHEMBL608840 | — | — | 1 | 8.80 |
| CHEMBL612051 | — | — | 1 | 8.72 |
| CHEMBL612044 | — | — | 1 | 8.58 |
| CHEMBL609103 | — | — | 1 | 8.50 |
| CHEMBL608838 | — | — | 1 | 8.50 |
| CHEMBL611776 | — | — | 1 | 8.49 |
| CHEMBL612042 | — | — | 1 | 8.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL611772 | — | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL611766 | — | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL612049 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL612048 | — | Ki | = | 0.46 | nM | 9.34 |
| CHEMBL611785 | — | Ki | = | 0.48 | nM | 9.32 |
| CHEMBL609105 | — | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL612052 | — | Ki | = | 0.57 | nM | 9.24 |
| CHEMBL608839 | — | Ki | = | 0.59 | nM | 9.23 |
| CHEMBL611784 | — | Ki | = | 0.61 | nM | 9.21 |
| CHEMBL611782 | — | Ki | = | 0.61 | nM | 9.21 |
| CHEMBL611775 | — | Ki | = | 0.63 | nM | 9.20 |
| CHEMBL609101 | — | Ki | = | 0.77 | nM | 9.11 |
| CHEMBL611780 | — | Ki | = | 0.86 | nM | 9.07 |
| CHEMBL612041 | — | Ki | = | 0.88 | nM | 9.06 |
| CHEMBL611774 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL611767 | — | Ki | = | 0.96 | nM | 9.02 |
| CHEMBL611783 | — | Ki | = | 0.95 | nM | 9.02 |
| CHEMBL608842 | — | Ki | = | 0.95 | nM | 9.02 |
| CHEMBL612040 | — | Ki | = | 1.13 | nM | 8.95 |
| CHEMBL612037 | — | Ki | = | 1.28 | nM | 8.89 |
| CHEMBL608843 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL609100 | — | Ki | = | 1.47 | nM | 8.83 |
| CHEMBL612057 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL608840 | — | Ki | = | 1.58 | nM | 8.80 |
| CHEMBL612051 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL612044 | — | Ki | = | 2.65 | nM | 8.58 |
| CHEMBL609103 | — | Ki | = | 3.16 | nM | 8.50 |
| CHEMBL608838 | — | Ki | = | 3.13 | nM | 8.50 |
| CHEMBL611776 | — | Ki | = | 3.23 | nM | 8.49 |
| CHEMBL612042 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL612046 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL371502 | — | Ki | = | 6.6 | nM | 8.18 |