Assay Detail
ADMET
CHEMBL999392
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Inhibition of human recombinant CYP2B6
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.37 | 4.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.61 |
| CHEMBL493001 | — | — | 1 | 4.61 |
| CHEMBL407034 | — | — | 1 | 4.35 |
| CHEMBL498373 | — | — | 1 | 4.16 |
| CHEMBL498371 | — | — | 1 | 4.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140 | CURCUMIN | IC50 | = | 24500.0 | nM | 4.61 |
| CHEMBL493001 | — | IC50 | = | 24800.0 | nM | 4.61 |
| CHEMBL407034 | — | IC50 | = | 44800.0 | nM | 4.35 |
| CHEMBL498373 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL498371 | — | IC50 | = | 74300.0 | nM | 4.13 |