Assay Detail
Functional
CHEMBL999605
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Inhibition of TNFalpha release in human whole blood
13
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Recent advances on phosphodiesterase 4 inhibitors for the treatment of asthma and chronic obstructive pulmonary disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.12 | 9.92 |
| ID50 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL452578 | — | — | 1 | 9.92 |
| CHEMBL323312 | — | — | 1 | 9.52 |
| CHEMBL32442 | CDP840 | — | 1 | 9.17 |
| CHEMBL453357 | — | — | 1 | 7.34 |
| CHEMBL81364 | — | — | 1 | 7.14 |
| CHEMBL372575 | — | — | 1 | 6.80 |
| CHEMBL70391 | — | — | 1 | 6.59 |
| CHEMBL511115 | CILOMILAST | 3.0 | 1 | 6.08 |
| CHEMBL88153 | CDC-801 | 2.0 | 1 | 5.60 |
| CHEMBL370220 | — | — | 1 | 5.11 |
| CHEMBL198432 | — | — | 1 | 5.08 |
| CHEMBL468 | THALIDOMIDE | 4.0 | 1 | - |
| CHEMBL27107 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL452578 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL323312 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL32442 | CDP840 | IC50 | = | 0.67 | nM | 9.17 |
| CHEMBL453357 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL81364 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL372575 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL70391 | — | IC50 | = | 254.0 | nM | 6.59 |
| CHEMBL511115 | CILOMILAST | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL88153 | CDC-801 | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL370220 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL198432 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL468 | THALIDOMIDE | IC50 | = | 200000.0 | nM | - |
| CHEMBL27107 | — | ID50 | = | 21.0 | uM | - |