Compound Detail
CHEMBL100566
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Basic Information
| ChEMBL ID | CHEMBL100566 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BRCCXAUQKZKZAB-QHCPKHFHSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
422.5
MW (Da)
3.25
ALogP
6
HBA
1
HBD
86.8
PSA (Ų)
0.52
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.02
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein farnesyltransferase CHEMBL2094108 | IC50 | 8.02 | 8.01 | 9.5 | 2 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 CHEMBL240 | IC50 | 5.09 | 5.09 | 8200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein farnesyltransferase | IC50 | = | 9.5 | nM | 8.02 | Concentration required to displace 50% of a potent radiolabeled FTI from farnesy... | 11520202 |
| Protein farnesyltransferase | IC50 | = | 10.0 | nM | 8.0 | In vitro inhibition of farnesyl transferase using purified recombinant human enz... | 11520202 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 | IC50 | = | 8200.0 | nM | 5.09 | Inhibition of human ERG channel | 19534531 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11520202 | 10.1021/jm010156p | Protein farnesyltransferase | 2 |
| 11520202 | 10.1021/jm010156p | Geranylgeranyl transferase type-1 subunit beta | 1 |
| 11520202 | 10.1021/jm010156p | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 19534531 | 10.1021/jm900002x | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
Data from ChEMBL 36 via Core Engine