Compound Detail
CHEMBL1006
AMIFOSTINE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1006 |
| Name | AMIFOSTINE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | JKOQGQFVAUAYPM-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
| Active Moiety | CHEMBL1201382 |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
20
Publications
14
Known Names
20
Indications
1
Mechanisms
Molecular Properties
214.2
MW (Da)
-0.25
ALogP
4
HBA
4
HBD
95.6
PSA (Ų)
0.34
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1995 |
| Availability | Discontinued |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Reactive metabolite scavenging agent | - | - | ✓ | ✓ |
Indications
Head and Neck Neoplasms Head and Neck Neoplasms Ovarian Neoplasms Xerostomia Carcinoma Hepatoblastoma Lung Neoplasms Multiple Myeloma Peripheral Nervous System Diseases Trigeminal Neuralgia Breast Neoplasms Central Nervous System Neoplasms Colorectal Neoplasms Endometrial Neoplasms Fallopian Tube Neoplasms Hodgkin Disease Leukemia Lymphoma Lymphoma, Non-Hodgkin Myelodysplastic Syndromes
ATC Classification
V03AF05
amifostine
Level 1: VARIOUS
Level 2: ALL OTHER THERAPEUTIC PRODUCTS
Activity Summary
IC50 2 meas. best 5.71
Ki 1 meas. best 6.18
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(3) dopamine receptor CHEMBL234 | Ki | 6.18 | 6.18 | 655.0 | 1 |
| D(3) dopamine receptor CHEMBL234 | IC50 | 5.71 | 5.71 | 1929.0 | 1 |
| Radical scavenging activity CHEMBL613712 | IC50 | 4.0 | 4.0 | 100000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(3) dopamine receptor | Ki | = | 655.0 | nM | 6.18 | DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) | - |
| D(3) dopamine receptor | IC50 | = | 1929.0 | nM | 5.71 | DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) | - |
| Radical scavenging activity | IC50 | = | 100000.0 | nM | 4.0 | Antioxidant activity assessed as DPPH free radical scavenging activity by UV spe... | 19502068 |
Literature References
Data from ChEMBL 36 via Core Engine