Compound Detail
CHEMBL100793
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Basic Information
| ChEMBL ID | CHEMBL100793 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NZNNWFPVQYZJNH-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
296.3
MW (Da)
1.02
ALogP
6
HBA
2
HBD
113.7
PSA (Ų)
0.62
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.28
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sulfonylurea receptor 1, Kir6.2 CHEMBL2096972 | EC50 | 6.28 | 6.28 | 530.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sulfonylurea receptor 1, Kir6.2 | EC50 | = | 530.0 | nM | 6.28 | Inhibition of Beta-cell KATP channel | 12270187 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15887958 | 10.1021/jm0311339 | Rattus norvegicus | 8 |
| 12270187 | 10.1016/s0960-894x(02)00617-0 | Sulfonylurea receptor 1, Kir6.2 | 2 |
| 12270187 | 10.1016/s0960-894x(02)00617-0 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine