Assay Detail
Functional
CHEMBL653239
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Inhibition of Beta-cell KATP channel
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of 7-substituted-3-cyclobutylamino-4H-1,2,4-benzothiadiazine-1,1-dioxide derivatives as K(ATP) channel agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.73 | 6.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL318931 | — | — | 1 | 6.71 |
| CHEMBL102025 | — | — | 1 | 6.45 |
| CHEMBL100793 | — | — | 1 | 6.28 |
| CHEMBL319596 | — | — | 1 | 5.71 |
| CHEMBL319521 | — | — | 1 | 5.41 |
| CHEMBL181 | DIAZOXIDE | 4.0 | 1 | 5.06 |
| CHEMBL101736 | — | — | 1 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL318931 | — | EC50 | = | 196.0 | nM | 6.71 |
| CHEMBL102025 | — | EC50 | = | 356.0 | nM | 6.45 |
| CHEMBL100793 | — | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL319596 | — | EC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL319521 | — | EC50 | = | 3870.0 | nM | 5.41 |
| CHEMBL181 | DIAZOXIDE | EC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL101736 | — | EC50 | = | 31000.0 | nM | 4.51 |