Compound Detail
CHEMBL319596
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL319596 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HWUFEDVHNRSSFJ-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
251.3
MW (Da)
1.30
ALogP
4
HBA
2
HBD
70.6
PSA (Ų)
0.79
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 5.71
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sulfonylurea receptor 1, Kir6.2 CHEMBL2096972 | EC50 | 5.71 | 5.705 | 1960.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sulfonylurea receptor 1, Kir6.2 | EC50 | = | 1960.0 | nM | 5.71 | Inhibition of Beta-cell KATP channel | 12270187 |
| Sulfonylurea receptor 1, Kir6.2 | EC50 | = | 1995.26 | nM | 5.7 | Negative log EC50 for Beta-cell KATP channel | 12270187 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15887958 | 10.1021/jm0311339 | Rattus norvegicus | 8 |
| 12270187 | 10.1016/s0960-894x(02)00617-0 | Sulfonylurea receptor 1, Kir6.2 | 3 |
Data from ChEMBL 36 via Core Engine