Assay Detail
Functional
CHEMBL858103
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Negative log EC50 for Beta-cell KATP channel
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of 7-substituted-3-cyclobutylamino-4H-1,2,4-benzothiadiazine-1,1-dioxide derivatives as K(ATP) channel agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.74 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL318931 | — | — | 1 | 6.70 |
| CHEMBL102025 | — | — | 1 | 6.40 |
| CHEMBL319596 | — | — | 1 | 5.70 |
| CHEMBL319521 | — | — | 1 | 5.40 |
| CHEMBL101736 | — | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL318931 | — | EC50 | = | 199.53 | nM | 6.70 |
| CHEMBL102025 | — | EC50 | = | 398.11 | nM | 6.40 |
| CHEMBL319596 | — | EC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL319521 | — | EC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL101736 | — | EC50 | = | 31622.78 | nM | 4.50 |