Compound Detail
CHEMBL101736
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Basic Information
| ChEMBL ID | CHEMBL101736 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AJJGPEYPBZRNCG-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
266.3
MW (Da)
0.69
ALogP
5
HBA
3
HBD
96.6
PSA (Ų)
0.65
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 4.51
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sulfonylurea receptor 1, Kir6.2 CHEMBL2096972 | EC50 | 4.51 | 4.505 | 31000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sulfonylurea receptor 1, Kir6.2 | EC50 | = | 31000.0 | nM | 4.51 | Inhibition of Beta-cell KATP channel | 12270187 |
| Sulfonylurea receptor 1, Kir6.2 | EC50 | = | 31622.78 | nM | 4.5 | Negative log EC50 for Beta-cell KATP channel | 12270187 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12270187 | 10.1016/s0960-894x(02)00617-0 | Sulfonylurea receptor 1, Kir6.2 | 3 |
Data from ChEMBL 36 via Core Engine