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Compound Detail

CHEMBL100870

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Oc1ccc(OCCN2CCC(c3ccccc3)CC2)cc1

Basic Information

ChEMBL ID CHEMBL100870
Phase Preclinical
Structure Type MOL
InChI Key JRNIKKDZNLWUQY-UHFFFAOYSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

297.4
MW (Da)
3.65
ALogP
3
HBA
1
HBD
32.7
PSA (Ų)
0.91
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H23NO2
MW 297.40
Aromatic Rings 2
Heavy Atoms 22
NP-Likeness -0.65

Activity Summary

IC50 2 meas. best 5.11

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Glutamate NMDA receptor; Grin1/Grin2b
CHEMBL2096666
IC50 5.11 5.11 7700.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
10425109 10.1021/jm990246i Glutamate NMDA receptor; Grin1/Grin2a 1
10425109 10.1021/jm990246i Glutamate NMDA receptor; Grin1/Grin2b 1
10425109 10.1021/jm990246i Glutamate NMDA receptor; Grin1/Grin2c 1

Data from ChEMBL 36 via Core Engine