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Compound Detail

CHEMBL102588

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Clc1cncc(C2CN3CCC2CC3)n1

Basic Information

ChEMBL ID CHEMBL102588
Phase Preclinical
Structure Type MOL
InChI Key SVYQJDWKZFJOEJ-UHFFFAOYSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

223.7
MW (Da)
1.94
ALogP
3
HBA
0
HBD
29.0
PSA (Ų)
0.73
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C11H14ClN3
MW 223.71
Aromatic Rings 1
Heavy Atoms 15
NP-Likeness -0.09

Activity Summary

IC50 2 meas. best 8.34

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M1
CHEMBL276
IC50 8.34 8.335 4.6 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
1732546 10.1021/jm00080a014 Muscarinic acetylcholine receptor 3
7658434 10.1021/jm00018a007 Muscarinic acetylcholine receptor M1 2
7658434 10.1021/jm00018a007 Mus musculus 2
7658434 10.1021/jm00018a007 A9 1

Data from ChEMBL 36 via Core Engine