Compound Detail
CHEMBL1078237
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Basic Information
| ChEMBL ID | CHEMBL1078237 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BRRQXQHULRURAR-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
272.7
MW (Da)
3.73
ALogP
3
HBA
1
HBD
55.1
PSA (Ų)
0.77
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hypoxia-inducible factor 1-alpha CHEMBL4261 | IC50 | 5.64 | 5.64 | 2300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hypoxia-inducible factor 1-alpha | IC50 | = | 2300.0 | nM | 5.64 | Inhibition of HIF-1alpha (unknown origin) transcriptional activity expressed in ... | 36518694 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19783434 | 10.1016/j.bmcl.2009.09.010 | Ephrin type-B receptor 3 | 1 |
| 36518694 | 10.1021/acsmedchemlett.2c00308 | Hypoxia-inducible factor 1-alpha | 1 |
| 36518694 | 10.1021/acsmedchemlett.2c00308 | HEK-293T | 1 |
Data from ChEMBL 36 via Core Engine