Compound Detail
CHEMBL1084168
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Basic Information
| ChEMBL ID | CHEMBL1084168 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KTVAHYZLKKQAOW-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
282.3
MW (Da)
0.51
ALogP
5
HBA
2
HBD
109.7
PSA (Ų)
0.54
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 5.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Homo sapiens CHEMBL372 | EC50 | 5.82 | 5.82 | 1500.0 | 1 |
| Parathyroid hormone/parathyroid hormone-related peptide receptor CHEMBL1793 | EC50 | 5.5 | 5.5 | 3200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Homo sapiens | EC50 | = | 1500.0 | nM | 5.82 | Antiosteoporotic activity in men with osteoporosis assessed as decrease in bone ... | 20218623 |
| Parathyroid hormone/parathyroid hormone-related peptide receptor | EC50 | = | 3200.0 | nM | 5.5 | Agonist activity at PTH1R overexpressed in HEK293 cells assessed as intracellula... | 20218623 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20218623 | 10.1021/jm9018756 | Homo sapiens | 1 |
| 20218623 | 10.1021/jm9018756 | Parathyroid hormone/parathyroid hormone-related peptide receptor | 1 |
Data from ChEMBL 36 via Core Engine