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Compound Detail

CHEMBL1094977

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NC(Cc1ccc(O)n[n+]1[O-])C(=O)O

Basic Information

ChEMBL ID CHEMBL1094977
Phase Preclinical
Structure Type MOL
InChI Key JIGIMLJTWNZFQN-UHFFFAOYSA-N
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

199.2
MW (Da)
-1.62
ALogP
5
HBA
3
HBD
123.4
PSA (Ų)
0.40
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C7H9N3O4
MW 199.17
Aromatic Rings 1
Heavy Atoms 14
NP-Likeness 0.15

Activity Summary

EC50 4 meas. best 6.59

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Glutamate receptor 1
CHEMBL2009
EC50 6.59 6.585 258.0 2
Glutamate receptor 3
CHEMBL3595
EC50 4.38 4.38 41600.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
20096591 10.1016/j.bmc.2009.12.072 Glutamate receptor 1 2
20096591 10.1016/j.bmc.2009.12.072 Glutamate receptor 3 2
20096591 10.1016/j.bmc.2009.12.072 Unchecked 1

Data from ChEMBL 36 via Core Engine