Compound Detail
CHEMBL1097199
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Nc1nc2c(c(=O)[nH]1)[n+](Cc1cccc(Cl)c1)cn2[C@@H]1O[C@H](COP(=O)([O-])O)[C@@H](O)[C@H]1O
Basic Information
| ChEMBL ID | CHEMBL1097199 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LNHYRHWHNOSCLV-XNIJJKJLSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
487.8
MW (Da)
-1.61
ALogP
10
HBA
5
HBD
199.9
PSA (Ų)
0.20
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.25
Kd 1 meas. best 5.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Eukaryotic translation initiation factor 4E CHEMBL6148 | Kd | 5.66 | 5.66 | 2200.0 | 1 |
| Eukaryotic translation initiation factor 4E CHEMBL4848 | IC50 | 4.25 | 4.25 | 56800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Eukaryotic translation initiation factor 4E | Kd | = | 2200.0 | nM | 5.66 | Binding affinity to mouse eIF4E expressed in Escherichia coli by fluorescence ti... | 20060622 |
| Eukaryotic translation initiation factor 4E | IC50 | = | 56800.0 | nM | 4.25 | Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E exp... | 22458568 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20060622 | 10.1016/j.ejmech.2009.11.054 | Eukaryotic translation initiation factor 4E | 4 |
| 22458568 | 10.1021/jm300037x | Eukaryotic translation initiation factor 4E | 1 |
Data from ChEMBL 36 via Core Engine