Compound Detail
CHEMBL1098157
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Cn1cnc(-c2cc3nccc(Oc4ccc(NC(=O)c5cnn(C)c5C(F)(F)F)cc4F)c3s2)c1
Basic Information
| ChEMBL ID | CHEMBL1098157 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QWBMMYUQYVEPPM-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
516.5
MW (Da)
5.63
ALogP
8
HBA
1
HBD
86.9
PSA (Ų)
0.31
QED
2
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hepatocyte growth factor receptor CHEMBL3717 | IC50 | 7.22 | 7.22 | 60.0 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 6.16 | 6.16 | 700.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hepatocyte growth factor receptor | IC50 | = | 60.0 | nM | 7.22 | Inhibition of c-Met | 20363625 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 700.0 | nM | 6.16 | Inhibition of VEGFR2 | 20363625 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20363625 | 10.1016/j.bmcl.2010.03.073 | Macrophage-stimulating protein receptor | 1 |
| 20363625 | 10.1016/j.bmcl.2010.03.073 | Hepatocyte growth factor receptor | 1 |
| 20363625 | 10.1016/j.bmcl.2010.03.073 | Vascular endothelial growth factor receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine