Compound Detail
CHEMBL111297
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Basic Information
| ChEMBL ID | CHEMBL111297 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NIYSRNQNNDXDIU-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
394.3
MW (Da)
4.30
ALogP
4
HBA
1
HBD
49.7
PSA (Ų)
0.77
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.93
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sulfonylurea receptors; K-ATP channels CHEMBL2095152 | EC50 | 6.93 | 6.93 | 117.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sulfonylurea receptors; K-ATP channels | EC50 | = | 117.49 | nM | 6.93 | Evaluated for K-ATP activity in terms of membrane potential change, through guin... | 15163197 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15163197 | 10.1021/jm030357o | Sulfonylurea receptors; K-ATP channels | 2 |
Data from ChEMBL 36 via Core Engine