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Compound Detail

CHEMBL11155

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COc1ccc(CCNCC(O)COc2ccc(-c3nccs3)cc2)cc1OC

Basic Information

ChEMBL ID CHEMBL11155
Phase Preclinical
Structure Type MOL
InChI Key XGFGQWLLSGNLFP-UHFFFAOYSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

414.5
MW (Da)
3.40
ALogP
7
HBA
2
HBD
72.8
PSA (Ų)
0.47
QED
0
Ro5 Violations
11
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H26N2O4S
MW 414.53
Aromatic Rings 3
Heavy Atoms 29
NP-Likeness -0.90

Activity Summary

Kd 2 meas. best 7.23

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-1 adrenergic receptor
CHEMBL5471
Kd 7.23 7.23 58.9 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
2872332 10.1021/jm00156a028 No relevant target 1
2872332 10.1021/jm00156a028 Beta-1 adrenergic receptor 1
2872332 10.1021/jm00156a028 Beta-2 adrenergic receptor 1
2872332 10.1021/jm00156a028 Rattus norvegicus 1
2872332 10.1021/jm00156a028 Adrenergic receptor beta; ADRB1 & ADRB2 1

Data from ChEMBL 36 via Core Engine