Compound Detail
CHEMBL112024
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Basic Information
| ChEMBL ID | CHEMBL112024 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FJLSZBZWFBWFHE-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
344.4
MW (Da)
2.69
ALogP
5
HBA
1
HBD
62.5
PSA (Ų)
0.77
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 7.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 6 CHEMBL3371 | Ki | 7.72 | 7.635 | 19.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 6 | Ki | = | 19.0 | nM | 7.72 | Binding affinity as displacement of [3H]5-HT binding to 5-hydroxytryptamine 6 re... | 11689074 |
| 5-hydroxytryptamine receptor 6 | Ki | = | 28.0 | nM | 7.55 | Binding affinity towards human 5-hydroxytryptamine 6 receptor | 12951125 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12951125 | 10.1016/s0960-894x(03)00612-7 | 5-hydroxytryptamine receptor 6 | 1 |
| 11689074 | 10.1021/jm010943m | 5-hydroxytryptamine receptor 6 | 1 |
Data from ChEMBL 36 via Core Engine