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Assay Detail

CHEMBL618120

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity towards human 5-hydroxytryptamine 6 receptor
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

5-hydroxytryptamine receptor 6 (CHEMBL3371)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

N1-benzenesulfonylgramine and N1-benzenesulfonylskatole: novel 5-HT6 receptor ligand templates.
Pullagurla MR, Dukat M, Setola V, Roth B, Glennon RA.
Bioorg Med Chem Lett (2003) 13 : 3355 -3359
PubMed 12951125 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 18 8.10 9.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL326937 1 9.22
CHEMBL112296 1 9.22
CHEMBL94093 1 9.10
CHEMBL94569 1 8.70
CHEMBL76237 1 8.64
CHEMBL114048 1 8.52
CHEMBL94422 1 8.51
CHEMBL93868 1 8.39
CHEMBL333373 1 8.21
CHEMBL329739 1 8.16
CHEMBL328816 1 7.92
CHEMBL111943 1 7.64
CHEMBL324766 1 7.57
CHEMBL112024 1 7.55
CHEMBL419398 1 7.47
CHEMBL112285 1 7.37
CHEMBL322980 1 7.05
CHEMBL325428 1 6.64

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL326937 Ki = 0.6 nM 9.22
CHEMBL112296 Ki = 0.6 nM 9.22
CHEMBL94093 Ki = 0.8 nM 9.10
CHEMBL94569 Ki = 2.0 nM 8.70
CHEMBL76237 Ki = 2.3 nM 8.64
CHEMBL114048 Ki = 3.0 nM 8.52
CHEMBL94422 Ki = 3.1 nM 8.51
CHEMBL93868 Ki = 4.1 nM 8.39
CHEMBL333373 Ki = 6.2 nM 8.21
CHEMBL329739 Ki = 6.9 nM 8.16
CHEMBL328816 Ki = 12.0 nM 7.92
CHEMBL111943 Ki = 23.0 nM 7.64
CHEMBL324766 Ki = 27.0 nM 7.57
CHEMBL112024 Ki = 28.0 nM 7.55
CHEMBL419398 Ki = 34.0 nM 7.47
CHEMBL112285 Ki = 43.0 nM 7.37
CHEMBL322980 Ki = 90.0 nM 7.05
CHEMBL325428 Ki = 230.0 nM 6.64