Compound Detail
CHEMBL333373
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL333373 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WCGNBIHZQHGUFA-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
386.5
MW (Da)
3.77
ALogP
5
HBA
0
HBD
51.5
PSA (Ų)
0.59
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 8.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 6 CHEMBL3371 | Ki | 8.22 | 8.215 | 6.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 6 | Ki | = | 6.0 | nM | 8.22 | Binding affinity against 5-hydroxytryptamine 6 receptor | 15357994 |
| 5-hydroxytryptamine receptor 6 | Ki | = | 6.2 | nM | 8.21 | Binding affinity towards human 5-hydroxytryptamine 6 receptor | 12951125 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12951125 | 10.1016/s0960-894x(03)00612-7 | 5-hydroxytryptamine receptor 6 | 1 |
| 15357994 | 10.1016/j.bmcl.2004.05.076 | 5-hydroxytryptamine receptor 6 | 1 |
Data from ChEMBL 36 via Core Engine