Compound Detail
CHEMBL1159809
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Basic Information
| ChEMBL ID | CHEMBL1159809 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NIAJBPNCQFEPJW-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
167.3
MW (Da)
0.01
ALogP
3
HBA
2
HBD
49.1
PSA (Ų)
0.46
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Aminopeptidase N CHEMBL1907 | IC50 | 7.7 | 7.7 | 20.0 | 1 |
| Aminopeptidase N CHEMBL2590 | IC50 | 7.7 | 7.7 | 20.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Aminopeptidase N | IC50 | = | 20.0 | nM | 7.7 | Inhibition of [3H]Leu-enkephalin binding to Aminopeptidase N from hog kidney | 1348542 |
| Aminopeptidase N | IC50 | = | 20.0 | nM | 7.7 | Inhibition of APN (unknown origin) | 29630364 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1348542 | 10.1021/jm00085a013 | Mus musculus | 6 |
| 1348542 | 10.1021/jm00085a013 | Aminopeptidase N | 1 |
| 29630364 | 10.1021/acs.jmedchem.7b00782 | Aminopeptidase N | 1 |
Data from ChEMBL 36 via Core Engine