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Compound Detail

CHEMBL1163244

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BrC1=NOC2CC3CNCC(C3)C12

Basic Information

ChEMBL ID CHEMBL1163244
Phase Preclinical
Structure Type MOL
InChI Key NPBPYBADQAKDGE-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

245.1
MW (Da)
1.34
ALogP
3
HBA
1
HBD
33.6
PSA (Ų)
0.70
QED
0
Ro5 Violations
0
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C9H13BrN2O
MW 245.12
Aromatic Rings 0
Heavy Atoms 13
NP-Likeness 0.34

Activity Summary

Ki 2 meas. best 6.04

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Neuronal acetylcholine receptor; alpha4/beta2
CHEMBL1907596
Ki 6.04 6.04 920.0 1
Neuronal acetylcholine receptor subunit alpha-7
CHEMBL4980
Ki 4.54 4.54 28500.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
20478710 10.1016/j.bmc.2010.04.065 Neuronal acetylcholine receptor; alpha4/beta2 1
20478710 10.1016/j.bmc.2010.04.065 Neuronal acetylcholine receptor subunit alpha-7 1

Data from ChEMBL 36 via Core Engine