Compound Detail
CHEMBL116368
AMIPIZONE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL116368 |
| Name | AMIPIZONE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | NQWQBGBWCJSARZ-UHFFFAOYSA-N |
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
9
Publications
2
Known Names
Molecular Properties
293.8
MW (Da)
2.11
ALogP
3
HBA
2
HBD
70.6
PSA (Ų)
0.84
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Racemic |
Activity Summary
IC50 4 meas. best 8.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Homo sapiens CHEMBL372 | IC50 | 8.0 | 6.92 | 10.0 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Homo sapiens | IC50 | = | 10.0 | nM | 8.0 | In vitro inhibition of ADP stimulated platelet aggregation in human whole blood | 2536438 |
| Homo sapiens | IC50 | = | 150.0 | nM | 6.82 | In vitro inhibition of collagen stimulated platelet aggregation in human thrombo... | 2536438 |
| Homo sapiens | IC50 | = | 350.0 | nM | 6.46 | In vitro inhibition of ADP stimulated platelet aggregation in human thrombocyte ... | 2536438 |
| Homo sapiens | IC50 | = | 400.0 | nM | 6.4 | In vitro inhibition of collagen stimulated platelet aggregation in human whole b... | 2536438 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2536438 | 10.1021/jm00122a011 | Canis familiaris | 12 |
| 6854582 | 10.1021/jm00360a004 | Rattus norvegicus | 4 |
| 2536438 | 10.1021/jm00122a011 | Homo sapiens | 4 |
| 6854582 | 10.1021/jm00360a004 | Homo sapiens | 3 |
| 6854582 | 10.1021/jm00360a004 | Unchecked | 1 |
| 2985781 | 10.1021/jm50001a001 | Phosphodiesterase 1 | 1 |
| 2985781 | 10.1021/jm50001a001 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 1 |
| 2985781 | 10.1021/jm50001a001 | Phosphodiesterase 3 | 1 |
| 2536438 | 10.1021/jm00122a011 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine