Assay Detail
Functional
CHEMBL878447
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of collagen stimulated platelet aggregation in human whole blood
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Cardiotonic agents. 9. Synthesis and biological evaluation of a series of (E)-4,5-dihydro-6-[2-[4-(1H-imidazol-1-yl)phenyl]ethenyl]-3 (2H)-pyridazinones: a novel class of compounds with positive inotropic, antithrombotic, and vasodilatory activities for the treatment of congestive heart failure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.13 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL544813 | — | — | 1 | 8.82 |
| CHEMBL189 | MILRINONE | 4.0 | 1 | 6.46 |
| CHEMBL116368 | AMIPIZONE | 2.0 | 1 | 6.40 |
| CHEMBL282765 | TETRAHYDROBENXIMIDAZOLE | — | 1 | 6.12 |
| CHEMBL332341 | — | — | 1 | 6.00 |
| CHEMBL12831 | IMAZODAN | 2.0 | 1 | 4.77 |
| CHEMBL440593 | CI-930 | — | 1 | 4.35 |
| CHEMBL12856 | INAMRINONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL544813 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL189 | MILRINONE | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL116368 | AMIPIZONE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL282765 | TETRAHYDROBENXIMIDAZOLE | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL332341 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL12831 | IMAZODAN | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL440593 | CI-930 | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL12856 | INAMRINONE | IC50 | = | 500000.0 | nM | - |