Compound Detail
CHEMBL1170784
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Basic Information
| ChEMBL ID | CHEMBL1170784 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZJESLKXOBQREAT-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
417.5
MW (Da)
3.35
ALogP
5
HBA
2
HBD
119.0
PSA (Ų)
0.74
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 9.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor CHEMBL1844 | IC50 | 9.3 | 9.3 | 0.5 | 1 |
| Macrophage colony-stimulating factor 1 CHEMBL3638330 | IC50 | 9.0 | 9.0 | 1.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 8.44 | 8.44 | 3.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor | IC50 | = | 0.5 | nM | 9.3 | Inhibition of human FMS by fluorescence polarization | 20570147 |
| Macrophage colony-stimulating factor 1 | IC50 | = | 1.0 | nM | 9.0 | Fluorescence Polarization Competition Immunoassay: A fluorescence polarization c... | - |
| Unchecked | IC50 | = | 3.6 | nM | 8.44 | Inhibition of CSF1-induced mouse BMDM cell proliferation | 20570147 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20570147 | 10.1016/j.bmcl.2010.05.013 | Unchecked | 3 |
| 20570147 | 10.1016/j.bmcl.2010.05.013 | Liver microsomes | 2 |
| 20570147 | 10.1016/j.bmcl.2010.05.013 | Macrophage colony-stimulating factor 1 receptor | 1 |
Data from ChEMBL 36 via Core Engine