Compound Detail
CHEMBL11754
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Basic Information
| ChEMBL ID | CHEMBL11754 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HZXALAHGWUIGAT-UHFFFAOYSA-M |
| Parent Compound | CHEMBL1178036 |
| Active Moiety | CHEMBL1178036 |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
518.8
MW (Da)
7.59
ALogP
4
HBA
0
HBD
48.6
PSA (Ų)
0.08
QED
2
Ro5 Violations
25
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.83
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Platelet-activating factor receptor CHEMBL5136 | IC50 | 5.83 | 5.83 | 1466.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Platelet-activating factor receptor | IC50 | = | 1466.0 | nM | 5.83 | In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/0960-894X(95)00173-Q | Platelet-activating factor receptor | 2 |
Data from ChEMBL 36 via Core Engine