Compound Detail
CHEMBL118478
ILEPCIMIDE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL118478 |
| Name | ILEPCIMIDE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | BLPUOQGPBJPXRL-FNORWQNLSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
10
Publications
3
Known Names
Molecular Properties
259.3
MW (Da)
2.44
ALogP
3
HBA
0
HBD
38.8
PSA (Ų)
0.77
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
EC50 1 meas. best 4.7
IC50 1 meas. best 4.01
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 1 CHEMBL4794 | EC50 | 4.7 | 4.7 | 19952.6 | 1 |
| Trypanosoma cruzi CHEMBL368 | IC50 | 4.01 | 4.01 | 97000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 1 | EC50 | = | 19952.62 | nM | 4.7 | Agonist activity at human TRPV1 expressed in tetracycline-stimulated HEK293 cell... | 20381363 |
| Trypanosoma cruzi | IC50 | = | 97000.0 | nM | 4.01 | Antimicrobial activity against Trypanosoma cruzi | 20185316 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20381363 | 10.1016/j.bmc.2010.03.013 | Transient receptor potential cation channel subfamily V member 1 | 3 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 3 |
| 15177472 | 10.1016/j.bmcl.2004.04.019 | Trypanosoma cruzi | 2 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| 20185316 | 10.1016/j.bmc.2010.01.068 | Trypanosoma cruzi | 1 |
| 24905252 | 10.1021/jm5002277 | GABA-A receptor; alpha-1/beta-2/gamma-2 | 1 |
| 30638966 | 10.1016/j.bmc.2018.12.043 | Polyunsaturated fatty acid 5-lipoxygenase | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
| 32402936 | 10.1016/j.ejmech.2020.112385 | PC-12 | 1 |
Data from ChEMBL 36 via Core Engine