Compound Detail
CHEMBL1187140
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Basic Information
| ChEMBL ID | CHEMBL1187140 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QFEIUMFDMLPLHS-UHFFFAOYSA-O |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
351.4
MW (Da)
3.80
ALogP
2
HBA
2
HBD
34.9
PSA (Ų)
0.42
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.51
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Telomerase reverse transcriptase CHEMBL2916 | IC50 | 6.51 | 6.51 | 310.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Telomerase reverse transcriptase | IC50 | = | 310.0 | nM | 6.51 | Inhibition of telomerase (unknown origin) | 35716866 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35716866 | 10.1016/j.bmcl.2022.128862 | Telomerase reverse transcriptase | 1 |
| 35716866 | 10.1016/j.bmcl.2022.128862 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine