Assay Detail
Binding
CHEMBL5105474
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Inhibition of telomerase (unknown origin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Indoloquinolines as scaffolds for the design of potent G-quadruplex ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.78 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1187140 | — | — | 1 | 6.51 |
| CHEMBL219728 | — | — | 1 | 6.40 |
| CHEMBL2260298 | — | — | 1 | 6.30 |
| CHEMBL274096 | — | — | 1 | 6.00 |
| CHEMBL276202 | — | — | 1 | 5.96 |
| CHEMBL5182039 | — | — | 1 | 5.20 |
| CHEMBL119096 | CRYPTOLEPINE | — | 1 | 5.03 |
| CHEMBL292124 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1187140 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL219728 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2260298 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL274096 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL276202 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5182039 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL119096 | CRYPTOLEPINE | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL292124 | — | IC50 | = | 16000.0 | nM | 4.80 |