Compound Detail
CHEMBL274096
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Basic Information
| ChEMBL ID | CHEMBL274096 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GDEUZHXVKFARAU-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
398.5
MW (Da)
5.39
ALogP
4
HBA
2
HBD
53.2
PSA (Ų)
0.38
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| DNA polymerase I, thermostable CHEMBL3564 | IC50 | 6.05 | 6.05 | 900.0 | 1 |
| Telomerase reverse transcriptase CHEMBL2916 | IC50 | 6.0 | 6.0 | 1000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| DNA polymerase I, thermostable | IC50 | = | 900.0 | nM | 6.05 | Tested for inhibitory activity against Taq DNA polymerase | 11909720 |
| Telomerase reverse transcriptase | IC50 | = | 1000.0 | nM | 6.0 | Tested for inhibitory activity against Telomerase in telomerase repeat amplifica... | 11909720 |
| Telomerase reverse transcriptase | IC50 | = | 1000.0 | nM | 6.0 | Inhibition of telomerase (unknown origin) | 35716866 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11909720 | 10.1016/s0960-894x(02)00080-x | Telomerase reverse transcriptase | 1 |
| 11909720 | 10.1016/s0960-894x(02)00080-x | DNA polymerase I, thermostable | 1 |
| - | 10.1007/s00044-011-9594-4 | Telomerase reverse transcriptase | 1 |
| 35716866 | 10.1016/j.bmcl.2022.128862 | Telomerase reverse transcriptase | 1 |
| 35716866 | 10.1016/j.bmcl.2022.128862 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine