Assay Detail
Binding
CHEMBL878872
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Tested for inhibitory activity against Telomerase in telomerase repeat amplification protocol (TRAP) assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Benzoindoloquinolines interact with DNA tetraplexes and inhibit telomerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.82 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274335 | — | — | 1 | 6.30 |
| CHEMBL274096 | — | — | 1 | 6.00 |
| CHEMBL276202 | — | — | 1 | 5.96 |
| CHEMBL10763 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274335 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL274096 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL276202 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL10763 | — | IC50 | = | 9800.0 | nM | 5.01 |