Compound Detail
CHEMBL274335
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Basic Information
| ChEMBL ID | CHEMBL274335 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZIWRVVOPHMKGJU-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
413.5
MW (Da)
5.25
ALogP
5
HBA
2
HBD
87.1
PSA (Ų)
0.23
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Telomerase reverse transcriptase CHEMBL2916 | IC50 | 6.3 | 6.3 | 500.0 | 2 |
| DNA polymerase I, thermostable CHEMBL3564 | IC50 | 5.3 | 5.3 | 5000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Telomerase reverse transcriptase | IC50 | = | 500.0 | nM | 6.3 | Tested for inhibitory activity against Telomerase in telomerase repeat amplifica... | 11909720 |
| Telomerase reverse transcriptase | IC50 | = | 500.0 | nM | 6.3 | Inhibition of telomerase (unknown origin) by TRAP assay | 23974014 |
| DNA polymerase I, thermostable | IC50 | = | 5000.0 | nM | 5.3 | Tested for inhibitory activity against Taq DNA polymerase | 11909720 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11909720 | 10.1016/s0960-894x(02)00080-x | Telomerase reverse transcriptase | 1 |
| 11909720 | 10.1016/s0960-894x(02)00080-x | DNA polymerase I, thermostable | 1 |
| 23974014 | 10.1016/j.ejmech.2013.07.022 | Telomerase reverse transcriptase | 1 |
Data from ChEMBL 36 via Core Engine