Compound Detail
CHEMBL118779
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Basic Information
| ChEMBL ID | CHEMBL118779 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HSNHSINMVKFVRQ-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
301.2
MW (Da)
1.13
ALogP
8
HBA
2
HBD
144.3
PSA (Ų)
0.54
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 6.25
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | Ki | 6.25 | 6.25 | 560.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA | Ki | = | 560.0 | nM | 6.25 | Binding affinity for ionotropic glutamate receptor AMPA using [3H]AMPA as radiol... | 14505662 |
| Glutamate receptor ionotropic, AMPA | Ki | = | 560.0 | nM | 6.25 | Displacement of [3H]AMPA (5 nM) from ionotropic glutamate receptor AMPA of rat c... | 15380209 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 14505662 | 10.1016/s0960-894x(03)00740-6 | Rattus norvegicus | 2 |
| 14505662 | 10.1016/s0960-894x(03)00740-6 | Glutamate receptor ionotropic, AMPA | 1 |
| 14505662 | 10.1016/s0960-894x(03)00740-6 | Glutamate receptors; NMDA/AMPA | 1 |
| 15380209 | 10.1016/j.bmcl.2004.07.093 | Glutamate receptor ionotropic, AMPA | 1 |
Data from ChEMBL 36 via Core Engine