Assay Detail
Binding
CHEMBL702541
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for ionotropic glutamate receptor AMPA using [3H]AMPA as radioligand, bound to synaptic membranes prepared from rat cerebral cortex
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2093871) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis and AMPA receptor antagonistic activity of a novel class of quinoxalinecarboxylic acid with a substituted phenyl group at the C-7 position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 6.90 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118369 | — | — | 1 | 7.80 |
| CHEMBL538777 | — | — | 1 | 7.80 |
| CHEMBL554662 | — | — | 1 | 7.75 |
| CHEMBL555657 | — | — | 1 | 7.70 |
| CHEMBL116565 | — | — | 1 | 7.66 |
| CHEMBL118641 | — | — | 1 | 7.66 |
| CHEMBL323648 | — | — | 1 | 7.57 |
| CHEMBL117771 | — | — | 1 | 7.54 |
| CHEMBL545051 | — | — | 1 | 7.52 |
| CHEMBL115912 | — | — | 1 | 7.52 |
| CHEMBL331103 | — | — | 1 | 7.52 |
| CHEMBL445313 | — | — | 1 | 7.50 |
| CHEMBL332816 | — | — | 1 | 7.33 |
| CHEMBL119625 | ZONAMPANEL | 2.0 | 1 | 7.21 |
| CHEMBL222519 | NBQX | — | 1 | 7.19 |
| CHEMBL1627032 | — | — | 1 | 7.17 |
| CHEMBL115861 | — | — | 1 | 7.07 |
| CHEMBL119832 | — | — | 1 | 7.00 |
| CHEMBL13260 | YM-90K | — | 1 | 7.00 |
| CHEMBL326542 | — | — | 1 | 6.77 |
| CHEMBL325878 | — | — | 1 | 6.57 |
| CHEMBL326506 | — | — | 1 | 6.48 |
| CHEMBL326157 | — | — | 1 | 6.28 |
| CHEMBL118779 | — | — | 1 | 6.25 |
| CHEMBL331844 | — | — | 1 | 6.04 |
| CHEMBL119818 | — | — | 1 | 5.89 |
| CHEMBL116266 | — | — | 1 | 5.70 |
| CHEMBL122188 | — | — | 1 | 5.70 |
| CHEMBL119365 | — | — | 1 | 5.60 |
| CHEMBL118585 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118369 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL538777 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL554662 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL555657 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL116565 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL118641 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL323648 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL117771 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL545051 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL115912 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL331103 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL445313 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL332816 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL119625 | ZONAMPANEL | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL222519 | NBQX | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL1627032 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL115861 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL119832 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL13260 | YM-90K | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL326542 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL325878 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL326506 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL326157 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL118779 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL331844 | — | Ki | = | 910.0 | nM | 6.04 |
| CHEMBL119818 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL116266 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL122188 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL119365 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL118585 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL122128 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL445314 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL117502 | — | Ki | > | 900.0 | nM | - |