Compound Detail
CHEMBL119934
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Basic Information
| ChEMBL ID | CHEMBL119934 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OEQWGVQMUXYOJC-PLNGDYQASA-N |
2
Targets
5
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
285.3
MW (Da)
3.47
ALogP
4
HBA
1
HBD
53.7
PSA (Ų)
0.67
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 7.6
Target Activity Profile
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| K562 | IC50 | = | 25.0 | nM | 7.6 | Antiproliferative activity against human K562 cells assessed as growth inhibitio... | 25221651 |
| HL-60 | IC50 | = | 30.0 | nM | 7.52 | In vitro inhibitory concentration against proliferation of HL60 cells | 12877593 |
| HL-60 | IC50 | = | 30.0 | nM | 7.52 | Induction of apoptosis in Homo sapiens (human) HL60 cells | - |
| HL-60 | IC50 | = | 32.0 | nM | 7.5 | In vitro inhibitory concentration against proliferation of HL60R cells along wit... | 12877593 |
| HL-60 | IC50 | = | 35.0 | nM | 7.46 | In vitro inhibitory concentration against proliferation of HL60R cells | 12877593 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12877593 | 10.1021/jm030785u | HL-60 | 5 |
| 25221651 | 10.1021/ml5000959 | K562 | 2 |
| 19117761 | 10.1016/j.bmc.2008.12.002 | No relevant target | 1 |
| - | 10.1007/s00044-010-9450-y | HL-60 | 1 |
Data from ChEMBL 36 via Core Engine