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Compound Detail

CHEMBL1200411

ROPINIROLE HYDROCHLORIDE
💊 Approved Drug
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💊 Approved Drug
CCCN(CCC)CCc1cccc2c1CC(=O)N2.Cl
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1200411
Name ROPINIROLE HYDROCHLORIDE
Phase Approved
Structure Type MOL
InChI Key XDXHAEQXIBQUEZ-UHFFFAOYSA-N
Therapeutic ✓ Yes
Parent Compound CHEMBL589
Active Moiety CHEMBL589

Known Names

Adartrel Aimpart xl Clevor Ipinnia xl Ralnea xl Raponer xl Repinex xl Requip Requip xl Ropilynz xl Ropinirole (as hydrochloride) Ropinirole hcl +4 more
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
20
Publications
16
Known Names
2
Indications
1
Mechanisms

Molecular Properties

260.4
MW (Da)
2.85
ALogP
2
HBA
1
HBD
32.3
PSA (Ų)
0.82
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 1997
Availability Prescription
Chirality Achiral

Routes of Administration

Oral

Flags

Black Box Warning
USAN Year 1993

Extended Properties

Molecular Formula C16H25ClN2O
MW 296.84
Aromatic Rings 1
Heavy Atoms 19
NP-Likeness -0.47

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
D2-like dopamine receptor agonist AGONIST D2-like dopamine receptor ✓ ✓

Indications

Parkinson Disease Restless Legs Syndrome

Drug Warnings

Black Box Warning
General Warning
Country: United States

Activity Summary

IC50 1 meas. best 4.9

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Plasmodium falciparum
CHEMBL364
 IC50 4.9 4.9 12589.2 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Plasmodium falciparum IC50 = 12589.25 nM 4.9 Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR gr... 19734910

Literature References

PubMed DOI Target Context # Activities
- 10.6019/CHEMBL5058564 Fibroblast 5
- 10.6019/CHEMBL5058564 U2OS 4
- 10.6019/CHEMBL5058564 HEK-293T 3
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
- 10.6019/CHEMBL5209801 Apelin receptor 2
- 10.6019/CHEMBL5209801 Free fatty acid receptor 4 2
- 10.6019/CHEMBL5209801 Type-1 angiotensin II receptor 2
- 10.6019/CHEMBL5209801 Adhesion G-protein coupled receptor F1 2
- 10.6019/CHEMBL5209801 G-protein coupled receptor 35 2
- 10.6019/CHEMBL5209801 Beta-2 adrenergic receptor 2
- 10.6019/CHEMBL5209801 Glucagon-like peptide 1 receptor 2
- 10.6019/CHEMBL5209801 Glucose-dependent insulinotropic receptor 2
- 10.6019/CHEMBL4495565 SARS-CoV-2 2
- 10.6019/CHEMBL5209801 C5a anaphylatoxin chemotactic receptor 1 2
- 10.6019/CHEMBL5209801 Alpha-2A adrenergic receptor 2
- 10.6019/CHEMBL5209801 N-formyl peptide receptor 2 2
- 10.6019/CHEMBL5209801 CX3C chemokine receptor 1 2
- 10.6019/CHEMBL5209801 Sphingosine 1-phosphate receptor 1 2
26555041 10.1021/acs.jmedchem.5b01031 Rattus norvegicus 1
23571415 10.1124/mol.112.084152 Solute carrier organic anion transporter family member 1B1 1

Data from ChEMBL 36 via Core Engine