Compound Detail
CHEMBL1200413
TETRAHYDROZOLINE HYDROCHLORIDE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1200413 |
| Name | TETRAHYDROZOLINE HYDROCHLORIDE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | BJORNXNYWNIWEY-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
| Parent Compound | CHEMBL1266 |
| Active Moiety | CHEMBL1266 |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
16
Publications
7
Known Names
2
Indications
1
Mechanisms
Molecular Properties
200.3
MW (Da)
2.11
ALogP
2
HBA
1
HBD
24.4
PSA (Ų)
0.74
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1979 |
| Availability | Prescription |
| Chirality | Racemic |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Adrenergic receptor alpha agonist | AGONIST | Adrenergic receptor alpha | ✓ | ✓ |
Indications
Inflammation Pterygium
Activity Summary
IC50 2 meas. best 6.8
EC50 1 meas. best 6.81
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Trace amine-associated receptor 1 CHEMBL5857 | EC50 | 6.81 | 6.81 | 154.4 | 1 |
| Trace amine-associated receptor 1 CHEMBL5857 | IC50 | 6.8 | 6.8 | 157.1 | 1 |
| Plasmodium falciparum CHEMBL364 | IC50 | 4.8 | 4.8 | 15848.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Trace amine-associated receptor 1 | EC50 | = | 154.41 | nM | 6.81 | PubChem BioAssay. Fluorescence-based cell-based high throughput dose response as... | - |
| Trace amine-associated receptor 1 | IC50 | = | 157.06 | nM | 6.8 | PubChem BioAssay. Counterscreen for agonists of the human trace amine associated... | - |
| Plasmodium falciparum | IC50 | = | 15848.93 | nM | 4.8 | Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR g... | 19734910 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 17417631 | 10.1038/nchembio873 | Unchecked | 1 |
| 19734910 | 10.1038/nchembio.215 | Plasmodium falciparum | 1 |
| 23571415 | 10.1124/mol.112.084152 | Solute carrier organic anion transporter family member 1B3 | 1 |
| 23571415 | 10.1124/mol.112.084152 | Solute carrier organic anion transporter family member 1B1 | 1 |
| - | 10.1101/2020.04.03.023846 | SARS-CoV-2 | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
| - | 10.6019/CHEMBL4513141 | Candida albicans | 1 |
| - | 10.6019/CHEMBL4513141 | Cryptococcus neoformans | 1 |
| - | 10.6019/CHEMBL4513141 | Escherichia coli | 1 |
| - | 10.6019/CHEMBL4513141 | Klebsiella pneumoniae | 1 |
| - | 10.6019/CHEMBL4513141 | Pseudomonas aeruginosa | 1 |
| - | 10.6019/CHEMBL4513141 | Acinetobacter baumannii | 1 |
| - | 10.6019/CHEMBL4513141 | Staphylococcus aureus | 1 |
Data from ChEMBL 36 via Core Engine