Compound Detail
CHEMBL1200728
GUANIDINE HYDROCHLORIDE 💊 Approved Drug
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💊 Approved Drug
0
Targets
13
Activities
3
Assay Types
0
PK Parameters
9
Publications
2
Known Names
3
Indications
1
Mechanisms
Molecular Properties
59.1
MW (Da)
-1.16
ALogP
1
HBA
3
HBD
75.9
PSA (Ų)
0.24
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1939 |
| Availability | Discontinued |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Voltage-gated potassium channel blocker | BLOCKER | Voltage-gated potassium channel | ✓ | ✓ |
Indications
Carcinoma, Small Cell Lambert-Eaton Myasthenic Syndrome Muscle Weakness
Activity Summary
EC50 7 meas.
IC50 5 meas.
Ki 1 meas.
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32250117 | 10.1021/acs.jmedchem.9b01955 | L-lactate dehydrogenase B chain | 18 |
| 31881489 | 10.1016/j.ejmech.2019.112007 | Coxsackievirus B3 | 5 |
| 31447248 | 10.1016/j.bmc.2019.115052 | Complement C5 | 4 |
| 20014752 | 10.1021/tx900326k | Hepatotoxicity | 3 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| 25466178 | 10.1016/j.bmcl.2014.11.004 | Nucleic Acid | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
| 36063653 | 10.1016/j.bmc.2022.116970 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine