Compound Detail
CHEMBL1200959
METHDILAZINE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1200959 |
| Name | METHDILAZINE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | HTMIBDQKFHUPSX-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
3
Known Names
1
Indications
1
Mechanisms
Molecular Properties
296.4
MW (Da)
4.24
ALogP
3
HBA
0
HBD
6.5
PSA (Ų)
0.82
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1982 |
| Availability | Discontinued |
| Chirality | Racemic |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Histamine H1 receptor antagonist | ANTAGONIST | Histamine H1 receptor | ✓ | ✓ |
Indications
Hypersensitivity
ATC Classification
R06AD04
methdilazine
Level 1: RESPIRATORY SYSTEM
Level 2: ANTIHISTAMINES FOR SYSTEMIC USE
Activity Summary
IC50 2 meas. best 5.2
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 5.2 | 5.2 | 6250.0 | 1 |
| Chikungunya virus CHEMBL4296563 | IC50 | 4.95 | 4.95 | 11300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 6250.0 | nM | 5.2 | In Vitro Protease Cleavage Assay: To screen for small molecular weight compounds... | - |
| Chikungunya virus | IC50 | = | 11300.0 | nM | 4.95 | Antiviral activity against Chikungunya virus LR2006 OPY1 infected in BHK cells m... | 28689975 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 4 |
| 28689975 | 10.1016/j.bmc.2017.06.049 | Unchecked | 2 |
| - | 10.6019/CHEMBL4651402 | Vero C1008 | 2 |
| 28689975 | 10.1016/j.bmc.2017.06.049 | Chikungunya virus | 1 |
Data from ChEMBL 36 via Core Engine