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Compound Detail

CHEMBL1200974

CARBINOXAMINE MALEATE
💊 Approved Drug
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💊 Approved Drug
CN(C)CCOC(c1ccc(Cl)cc1)c1ccccn1.O=C(O)/C=C\C(=O)O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1200974
Name CARBINOXAMINE MALEATE
Phase Approved
Structure Type MOL
InChI Key GVNWHCVWDRNXAZ-BTJKTKAUSA-N
Therapeutic ✓ Yes
Parent Compound CHEMBL864
Active Moiety CHEMBL864

Known Names

Carbinoxamine maleate Clistin Davenol Karbinal er NSC-62362
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
10
Publications
5
Known Names
6
Indications
1
Mechanisms

Molecular Properties

290.8
MW (Da)
3.40
ALogP
3
HBA
0
HBD
25.4
PSA (Ų)
0.82
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 1982
Availability Prescription
Chirality Racemic

Routes of Administration

Oral

Extended Properties

Molecular Formula C20H23ClN2O5
MW 406.87
Aromatic Rings 2
Heavy Atoms 20
NP-Likeness -1.33

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Histamine H1 receptor antagonist ANTAGONIST Histamine H1 receptor ✓ ✓

Indications

Angioedema Conjunctivitis, Allergic Rhinitis, Allergic, Perennial Rhinitis, Allergic, Seasonal Rhinitis, Vasomotor Urticaria

Activity Summary

IC50 1 meas. best 4.67

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
 IC50 4.67 4.67 21375.9 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked IC50 = 21375.91 nM 4.67 PubChem BioAssay. insulin secretion from INS-1E cells in the presence of 5 mM gl... -

Literature References

PubMed DOI Target Context # Activities
23571415 10.1124/mol.112.084152 Solute carrier organic anion transporter family member 1B1 1
23571415 10.1124/mol.112.084152 Solute carrier organic anion transporter family member 1B3 1
- 10.1101/2020.04.03.023846 SARS-CoV-2 1
- 10.6019/CHEMBL4513141 Candida albicans 1
- 10.6019/CHEMBL4513141 Cryptococcus neoformans 1
- 10.6019/CHEMBL4513141 Escherichia coli 1
- 10.6019/CHEMBL4513141 Klebsiella pneumoniae 1
- 10.6019/CHEMBL4513141 Pseudomonas aeruginosa 1
- 10.6019/CHEMBL4513141 Acinetobacter baumannii 1
- 10.6019/CHEMBL4513141 Staphylococcus aureus 1

Data from ChEMBL 36 via Core Engine